Cerivastatin Synergizes with Trametinib and Enhances Its Efficacy in the Therapy of Uveal Melanoma

SIMPLE SUMMARY: Uveal melanoma is a rare and aggressive disease. Gα-proteins GNAQ and GNA11 are driver mutations that activate MAP kinase and YAP/TAZ pathways. BAP1 loss and monosomy of chromosome 3 are present in patients with high risk of metastasis. MEK-inhibitors do not significantly block UM pr...

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Detalles Bibliográficos
Autores principales: Amaro, Adriana Agnese, Gangemi, Rosaria, Emionite, Laura, Castagnola, Patrizio, Filaci, Gilberto, Jager, Martine J., Tanda, Enrica Teresa, Spagnolo, Francesco, Mascherini, Matteo, Pfeffer, Ulrich, Croce, Michela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913575/
https://www.ncbi.nlm.nih.gov/pubmed/36765842
http://dx.doi.org/10.3390/cancers15030886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913575/
https://www.ncbi.nlm.nih.gov/pubmed/36765842
http://dx.doi.org/10.3390/cancers15030886

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