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Cerivastatin Synergizes with Trametinib and Enhances Its Efficacy in the Therapy of Uveal Melanoma

SIMPLE SUMMARY: Uveal melanoma is a rare and aggressive disease. Gα-proteins GNAQ and GNA11 are driver mutations that activate MAP kinase and YAP/TAZ pathways. BAP1 loss and monosomy of chromosome 3 are present in patients with high risk of metastasis. MEK-inhibitors do not significantly block UM pr...

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Detalles Bibliográficos
Autores principales:	Amaro, Adriana Agnese, Gangemi, Rosaria, Emionite, Laura, Castagnola, Patrizio, Filaci, Gilberto, Jager, Martine J., Tanda, Enrica Teresa, Spagnolo, Francesco, Mascherini, Matteo, Pfeffer, Ulrich, Croce, Michela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913575/ https://www.ncbi.nlm.nih.gov/pubmed/36765842 http://dx.doi.org/10.3390/cancers15030886

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