SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation

SIMPLE SUMMARY: Gene coding for the SOCS1 protein is frequently inactivated in liver cancer, suggesting that SOCS1 protects liver cells from becoming cancerous. This notion is supported by the increased susceptibility of mice lacking SOCS1 to develop liver cancer. Understanding how the SOCS1 protein...

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Detalles Bibliográficos
Autores principales: Khan, Md Gulam Musawwir, Boufaied, Nadia, Yeganeh, Mehdi, Kandhi, Rajani, Petkiewicz, Stephanie, Sharma, Ankur, Yoshimura, Akihiko, Ferbeyre, Gerardo, Labbé, David P., Ramanathan, Sheela, Ilangumaran, Subburaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913612/
https://www.ncbi.nlm.nih.gov/pubmed/36765862
http://dx.doi.org/10.3390/cancers15030905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913612/
https://www.ncbi.nlm.nih.gov/pubmed/36765862
http://dx.doi.org/10.3390/cancers15030905

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