The Landscape of Secondary Genetic Rearrangements in Pediatric Patients with B-Cell Acute Lymphoblastic Leukemia with t(12;21)

The most frequent chromosomal rearrangement in childhood B-cell acute lymphoblastic leukemia (B-ALL) is translocation t(12;21)(p13;q22). It results in the fusion of the ETV6::RUNX1 gene, which is active in the regulation of multiple crucial cellular pathways. Recent studies hypothesize that many tra...

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Detalles Bibliográficos
Autores principales: Kaczmarska, Agnieszka, Derebas, Justyna, Pinkosz, Michalina, Niedźwiecki, Maciej, Lejman, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913634/
https://www.ncbi.nlm.nih.gov/pubmed/36766699
http://dx.doi.org/10.3390/cells12030357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913634/
https://www.ncbi.nlm.nih.gov/pubmed/36766699
http://dx.doi.org/10.3390/cells12030357

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