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The Landscape of Secondary Genetic Rearrangements in Pediatric Patients with B-Cell Acute Lymphoblastic Leukemia with t(12;21)

The most frequent chromosomal rearrangement in childhood B-cell acute lymphoblastic leukemia (B-ALL) is translocation t(12;21)(p13;q22). It results in the fusion of the ETV6::RUNX1 gene, which is active in the regulation of multiple crucial cellular pathways. Recent studies hypothesize that many tra...

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Detalles Bibliográficos
Autores principales:	Kaczmarska, Agnieszka, Derebas, Justyna, Pinkosz, Michalina, Niedźwiecki, Maciej, Lejman, Monika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913634/ https://www.ncbi.nlm.nih.gov/pubmed/36766699 http://dx.doi.org/10.3390/cells12030357

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