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Mechanisms of ADC Toxicity and Strategies to Increase ADC Tolerability
SIMPLE SUMMARY: Antibody-drug conjugates (ADC) are a rapidly expanding class of anti-cancer drugs, with twelve agents in current clinical use. Despite recent successes, many ADCs fail during clinical development due to excessive toxicities and unfavorable risk-benefit profiles. Even for those ADCs t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913659/ https://www.ncbi.nlm.nih.gov/pubmed/36765668 http://dx.doi.org/10.3390/cancers15030713 |