Cargando…

Mechanisms of ADC Toxicity and Strategies to Increase ADC Tolerability

SIMPLE SUMMARY: Antibody-drug conjugates (ADC) are a rapidly expanding class of anti-cancer drugs, with twelve agents in current clinical use. Despite recent successes, many ADCs fail during clinical development due to excessive toxicities and unfavorable risk-benefit profiles. Even for those ADCs t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Toan D., Bordeau, Brandon M., Balthasar, Joseph P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913659/ https://www.ncbi.nlm.nih.gov/pubmed/36765668 http://dx.doi.org/10.3390/cancers15030713

Ejemplares similares

Novel ADCs and Strategies to Overcome Resistance to Anti-HER2 ADCs
por: Díaz-Rodríguez, Elena, et al.
Publicado: (2021)

The Chemistry Behind ADCs
por: Kostova, Vesela, et al.
Publicado: (2021)

Those ADCs
Publicado: (1971)

Current ADC Linker Chemistry
por: Jain, Nareshkumar, et al.
Publicado: (2015)

ADC : analog-to-digital converter reference manual.

Evaluating the Scope of Malignant Bone Tumor Using ADC Measurement on ADC Map
por: Chen, Haisong, et al.
Publicado: (2019)

Impact of Endocytosis Mechanisms for the Receptors Targeted by the Currently Approved Antibody-Drug Conjugates (ADCs)—A Necessity for Future ADC Research and Development
por: Hammood, Manar, et al.
Publicado: (2021)

New antibody-drug conjugates (ADCs) in breast cancer—an overview of ADCs recently approved and in later stages of development
por: Koster, Kira-Lee, et al.
Publicado: (2022)

Tumour ADC measurements in rectal cancer: effect of ROI methods on ADC values and interobserver variability
por: Lambregts, Doenja M. J., et al.
Publicado: (2011)

ANTIBODY DRUG CONJUGATES (ADCS)
por: Terpos, E.
Publicado: (2023)

LAr LTDB ADC’s calibration
por: Estevam De Paula, Rodrigo
Publicado: (2021)

Preamplifier/Shapers & ADC for Calorimeters
por: Schwemling, Philippe
Publicado: (2018)

Diffusion-Weighted Imaging for the Discrimination of Benign and Malignant Breast Masses; Utility of ADC and Relative ADC
por: Yılmaz, Ebru, et al.
Publicado: (2018)

Differentiation of Benign and Malignant Breast Lesions Using ADC Values and ADC Ratio in Breast MRI
por: Tsvetkova, Silvia, et al.
Publicado: (2022)

Site-Specific Antibody Conjugation for ADC and Beyond
por: Zhou, Qun
Publicado: (2017)

The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of Enterococcus faecalis virulence
por: Lam, Ling Ning, et al.
Publicado: (2022)

Strategies to enhance monoclonal antibody uptake and distribution in solid tumors
por: Bordeau, Brandon M., et al.
Publicado: (2021)

Endometrial Cancer Staging: Is There Value in ADC?
por: Moreira, Ana Sofia Linhares, et al.
Publicado: (2023)

Linearity investigation of ADC-TDC modules
por: Kulish, E, et al.
Publicado: (2011)

Systematic design for optimisation of pipelined ADCs
por: Goes, Joao
Publicado: (2001)

Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs)
por: Yao, Houzong, et al.
Publicado: (2016)

Analytical Methods for the Detection and Quantification of ADCs in Biological Matrices
por: Cahuzac, Héloïse, et al.
Publicado: (2020)

Potential of antibody–drug conjugates (ADCs) for cancer therapy
por: Marei, Hany E., et al.
Publicado: (2022)

A flash ADC system for TPC readout
por: Konoplyannikov, A K, et al.
Publicado: (1985)

Psychometric properties of the Alzheimer’s Disease Cooperative Study – Activities of Daily Living for Mild Cognitive Impairment (ADCS-MCI-ADL) scale: a post hoc analysis of the ADCS ADC-008 trial
por: Potashman, Michele, et al.
Publicado: (2023)

Development of an ADC Radiation Tolerance Characterization System for the Upgrade of the ATLAS LAr Calorimeter
por: Liu, Hongbin, et al.
Publicado: (2016)

Carte MDAC ADC-IO J24425
por: Georges, M
Publicado: (1998)

MPV908A-ADC driver: The MPV908A ADC VMEbus board driver under LynxOS
por: Abie, Habtamu, et al.
Publicado: (1992)

The Apparent Diffusion Coefficient (ADC) is a useful biomarker in predicting metastatic colon cancer using the ADC-value of the primary tumor
por: Nerad, Elias, et al.
Publicado: (2019)

Histogram-Based Calibration Method for Pipeline ADCs
por: Son, Hyeonuk, et al.
Publicado: (2015)

FPGA to high speed ADC data streaming
por: Gottardo, Marco
Publicado: (2018)

Digitally assisted pipeline ADCs: theory and implementation
por: Murmann, Boris, et al.
Publicado: (2007)

Eine Influenzdriftkammer mit Flash ADC Auslese
por: Sefzick, Thomas, et al.
Publicado: (1991)

Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC
por: Figueroa, Isabel, et al.
Publicado: (2018)

From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs)
por: Mantaj, Julia, et al.
Publicado: (2016)

Desynchronisation Problems Of The Bpm/raster Adc For E93050
por: Di Salvo, R, et al.
Publicado: (1999)

Digital Circuit for Seamless Resampling ADC Output Streams†
por: D’Arco, Mauro, et al.
Publicado: (2020)

Associations between apparent diffusion coefficient (ADC) and KI 67 in different tumors: a meta-analysis. Part 1: ADC(mean)
por: Surov, Alexey, et al.
Publicado: (2017)

Associations between apparent diffusion coefficient (ADC) and KI 67 in different tumors: a meta-analysis. Part 2: ADC(min)
por: Surov, Alexey, et al.
Publicado: (2018)

Characterization and in vitro data of antibody drug conjugates (ADCs) derived from heterotrifunctional linker designed for the site-specific preparation of dual ADCs
por: Kumar, Amit, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9n40qfhd24oegr1rqihpn8nbgr