GBM Cells Exhibit Susceptibility to Metformin Treatment According to TLR4 Pathway Activation and Metabolic and Antioxidant Status

SIMPLE SUMMARY: An analysis of metformin (MET) treatment in combination with temozolomide (TMZ) in two glioblastoma cell lines, U87MG and A172, stimulated with lipopolysaccharide (LPS), a TLR4 agonist was conducted. Both cells presented blunted mitochondrial respiration leading to oxidative stress a...

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Detalles Bibliográficos
Autores principales: Moretti, Isabele Fattori, Lerario, Antonio Marcondes, Sola, Paula Rodrigues, Macedo-da-Silva, Janaína, Baptista, Mauricio da Silva, Palmisano, Giuseppe, Oba-Shinjo, Sueli Mieko, Marie, Suely Kazue Nagahashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913744/
https://www.ncbi.nlm.nih.gov/pubmed/36765551
http://dx.doi.org/10.3390/cancers15030587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913744/
https://www.ncbi.nlm.nih.gov/pubmed/36765551
http://dx.doi.org/10.3390/cancers15030587

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