Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis

SIMPLE SUMMARY: We previously reported a novel mechanism of NRF2 tumoral immune suppression through selective upregulation of the tryptophan-metabolizing enzyme kynureninase (KYNU) in lung adenocarcinoma. In the current study, we report that elevated tumoral KYNU gene expression is broadly associate...

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Detalles Bibliográficos
Autores principales: León-Letelier, Ricardo A., Abdel Sater, Ali H., Chen, Yihui, Park, Soyoung, Wu, Ranran, Irajizad, Ehsan, Dennison, Jennifer B., Katayama, Hiroyuki, Vykoukal, Jody V., Hanash, Samir, Ostrin, Edwin J., Fahrmann, Johannes F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913753/
https://www.ncbi.nlm.nih.gov/pubmed/36765792
http://dx.doi.org/10.3390/cancers15030834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913753/
https://www.ncbi.nlm.nih.gov/pubmed/36765792
http://dx.doi.org/10.3390/cancers15030834

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