Enhancer Clusters Drive Type I Interferon-Induced TRAIL Overexpression in Cancer, and Its Intracellular Protein Accumulation Fails to Induce Apoptosis

SIMPLE SUMMARY: Upon interferon stimulation, cancer cells upregulate the pro-apoptotic cytokine TRAIL, but the mechanism of this upregulation remains unresolved. By examining the genomic regulatory landscape of TRAIL in cancer cells, we found that TRAIL is associated with large, densely clustered re...

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Detalles Bibliográficos
Autores principales: Di Benedetto, Carolina, Khan, Taimoor, Serrano-Saenz, Santiago, Rodriguez-Lemus, Anthony, Klomsiri, Chananat, Beutel, Tim-Mathis, Thach, Alysia, Walczak, Henning, Betancur, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913803/
https://www.ncbi.nlm.nih.gov/pubmed/36765925
http://dx.doi.org/10.3390/cancers15030967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913803/
https://www.ncbi.nlm.nih.gov/pubmed/36765925
http://dx.doi.org/10.3390/cancers15030967

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