Cargando…

IQGAP1 Is a Phosphotyrosine-Regulated Scaffold for SH2-Containing Proteins

The scaffold protein IQGAP1 associates with over 150 interactors to influence multiple biological processes. The molecular mechanisms that underly spatial and temporal regulation of these interactions, which are crucial for proper cell functions, remain poorly understood. The receptor tyrosine kinas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thines, Louise, Li, Zhigang, Sacks, David B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913818/ https://www.ncbi.nlm.nih.gov/pubmed/36766826 http://dx.doi.org/10.3390/cells12030483

Ejemplares similares

The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling
por: Thines, Louise, et al.
Publicado: (2023)

IQGAP1 and IQGAP2 are Reciprocally Altered in Hepatocellular Carcinoma
por: White, Colin D, et al.
Publicado: (2010)

Endogenous IQGAP1 and IQGAP3 do not functionally interact with Ras
por: Morgan, Chase J., et al.
Publicado: (2019)

Specificity and regulation of phosphotyrosine signaling through SH2 domains
por: Marasco, Michelangelo, et al.
Publicado: (2020)

IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway
por: Quinn, Niall P., et al.
Publicado: (2021)

The scaffold protein IQGAP1 is crucial for extravasation and metastasis
por: Hebert, Jess D., et al.
Publicado: (2020)

Conformational Determinants of Phosphotyrosine Peptides Complexed with the Src SH2 Domain
por: Nachman, Joseph, et al.
Publicado: (2010)

IQGAP1 binds AMPK and is required for maximum AMPK activation
por: Hedman, Andrew C., et al.
Publicado: (2020)

Discovery of small molecule inhibitors that effectively disrupt IQGAP1-Cdc42 interaction in breast cancer cells
por: Sayedyahossein, Samar, et al.
Publicado: (2022)

IQGAP1-Dependent Signaling Pathway Regulates Endothelial Cell Proliferation and Angiogenesis
por: Meyer, Rosana D., et al.
Publicado: (2008)

Solution Structure of Tensin2 SH2 Domain and Its Phosphotyrosine-Independent Interaction with DLC-1
por: Dai, Kun, et al.
Publicado: (2011)

Blockade of phosphotyrosine pathways suggesting SH2 superbinder as a novel therapy for pulmonary fibrosis
por: Wang, Meng, et al.
Publicado: (2022)

Endothelial IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of diapedesis
por: Sullivan, David P., et al.
Publicado: (2019)

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies
por: Kükenshöner, Tim, et al.
Publicado: (2017)

Paxillin is a major phosphotyrosine-containing protein during embryonic development
Publicado: (1991)

An Emerging Role for IQGAP1 in Regulating Protein Traffic
por: Osman, Mahasin
Publicado: (2010)

The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1
por: Liao, Yi-Chun, et al.
Publicado: (2007)

The scaffolding protein IQGAP1 co-localizes with actin at the cytoplasmic face of the nuclear envelope: implications for cytoskeletal regulation
por: Johnson, Michael A., et al.
Publicado: (2012)

(Arg)(9)-SH2 superbinder: a novel promising anticancer therapy to melanoma by blocking phosphotyrosine signaling
por: Liu, An-dong, et al.
Publicado: (2018)

The Antithetic Roles of IQGAP2 and IQGAP3 in Cancers
por: Song, Fei, et al.
Publicado: (2023)

Regulation of Spine Density and Morphology by IQGAP1 Protein Domains
por: Jausoro, Ignacio, et al.
Publicado: (2013)

IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice
por: Ghaleb, Amr M., et al.
Publicado: (2015)

Expanded Cellular Amino Acid Pools Containing Phosphoserine, Phosphothreonine, and Phosphotyrosine
por: Steinfeld, Justin B., et al.
Publicado: (2014)

A PAK6–IQGAP1 complex promotes disassembly of cell–cell adhesions
por: Fram, Sally, et al.
Publicado: (2013)

Shigella Effector OspB Activates mTORC1 in a Manner That Depends on IQGAP1 and Promotes Cell Proliferation
por: Lu, Richard, et al.
Publicado: (2015)

Phosphotyrosine-Mediated Regulation of Enterohemorrhagic Escherichia coli Virulence
por: Robertson, Colin D., et al.
Publicado: (2018)

Identification of Glioblastoma Phosphotyrosine-Containing Proteins with Two-Dimensional Western Blotting and Tandem Mass Spectrometry
por: Guo, Tianyao, et al.
Publicado: (2015)

Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro
por: Dong, Pei-Xin, et al.
Publicado: (2008)

Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction
por: Fahrenkamp, Dirk, et al.
Publicado: (2015)

Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues
por: Makukhin, Nikolai, et al.
Publicado: (2020)

A novel mechanism of ERK1/2 regulation in smooth muscle involving acetylation of the ERK1/2 scaffold IQGAP1
por: Vetterkind, Susanne, et al.
Publicado: (2017)

A phosphotyrosine switch regulates organic cation transporters
por: Sprowl, Jason A., et al.
Publicado: (2016)

Calmodulin activates the Hippo signaling pathway by promoting LATS1 kinase–mediated inhibitory phosphorylation of the transcriptional coactivator YAP
por: Thines, Louise, et al.
Publicado: (2022)

A highway to carcinogenesis: the role of IQGAP1, a signaling scaffolding protein, in head and neck cancer development
por: Wei, Tao, et al.
Publicado: (2020)

Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity
por: Kosol, Simone, et al.
Publicado: (2020)

β-Arrestin2 Regulates Lysophosphatidic Acid-Induced Human Breast Tumor Cell Migration and Invasion via Rap1 and IQGAP1
por: Alemayehu, Mistre, et al.
Publicado: (2013)

Role of IQGAP1 in Carcinogenesis
por: Wei, Tao, et al.
Publicado: (2021)

HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures
por: Shen, Xiaoli, et al.
Publicado: (2017)

IQ Motif Containing GTPase Activating Proteins (IQGAPs), A-Kinase Anchoring Proteins (AKAPs) and Kinase Suppressor of Ras Proteins (KSRs) in Scaffolding Oncogenic Pathways and Their Therapeutic Potential
por: Mohapatra, Talina, et al.
Publicado: (2022)

Discrete primary locations of a tyrosine-protein kinase and of three proteins that contain phosphotyrosine in virally transformed chick fibroblasts
Publicado: (1982)

Cannot write session to /tmp/vufind_sessions/sess_6kcju56pp2eh5bma8u4rcht6ab