Deletion of Glycogen Synthase Kinase 3 Beta Reprograms NK Cell Metabolism

SIMPLE SUMMARY: Natural killer (NK) cells from patients with acute myeloid leukemia (AML), or from healthy donors and expanded with IL-15, show defective cytotoxicity and elevated levels of glycogen synthase kinase 3 beta (GSK3β), and drug inhibition of GSK3β was able to improve their cytotoxicity a...

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Detalles Bibliográficos
Autores principales: Pereira, Marcelo S. F., Sorathia, Kinnari, Sezgin, Yasemin, Thakkar, Aarohi, Maguire, Colin, Collins, Patrick L., Mundy-Bosse, Bethany L., Lee, Dean A., Naeimi Kararoudi, Meisam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913837/
https://www.ncbi.nlm.nih.gov/pubmed/36765663
http://dx.doi.org/10.3390/cancers15030705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913837/
https://www.ncbi.nlm.nih.gov/pubmed/36765663
http://dx.doi.org/10.3390/cancers15030705

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