Synthesis and Biological Activity of a VHL-Based PROTAC Specific for p38α

SIMPLE SUMMARY: The compounds named PROTACs are formed by two fragments, which bring together a particular protein with a ubiquitinating enzyme. This allows ubiquitination and degradation of the targeted protein. Ubiquitination-mediated protein degradation is an important regulatory process to contr...

Descripción completa

Detalles Bibliográficos
Autores principales: Cubillos-Rojas, Mónica, Loren, Guillem, Hakim, Yusuf Z., Verdaguer, Xavier, Riera, Antoni, Nebreda, Angel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913880/
https://www.ncbi.nlm.nih.gov/pubmed/36765568
http://dx.doi.org/10.3390/cancers15030611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913880/
https://www.ncbi.nlm.nih.gov/pubmed/36765568
http://dx.doi.org/10.3390/cancers15030611

Ejemplares similares