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Synthesis and Biological Activity of a VHL-Based PROTAC Specific for p38α

SIMPLE SUMMARY: The compounds named PROTACs are formed by two fragments, which bring together a particular protein with a ubiquitinating enzyme. This allows ubiquitination and degradation of the targeted protein. Ubiquitination-mediated protein degradation is an important regulatory process to contr...

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Detalles Bibliográficos
Autores principales:	Cubillos-Rojas, Mónica, Loren, Guillem, Hakim, Yusuf Z., Verdaguer, Xavier, Riera, Antoni, Nebreda, Angel R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913880/ https://www.ncbi.nlm.nih.gov/pubmed/36765568 http://dx.doi.org/10.3390/cancers15030611

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