Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer’s Disease

Apolipoprotein E4 (ApoE4) is the most recognized genetic risk factor for late-onset Alzheimer’s disease (LOAD), whereas ApoE2 reduces the risk for LOAD. The underlying mechanisms are unclear but may include effects on brain energy metabolism. Here, we used neuro-2a (N2a) cells that stably express hu...

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Detalles Bibliográficos
Autores principales: Zhang, Xin, Wu, Long, Swerdlow, Russell H., Zhao, Liqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914046/
https://www.ncbi.nlm.nih.gov/pubmed/36766752
http://dx.doi.org/10.3390/cells12030410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914046/
https://www.ncbi.nlm.nih.gov/pubmed/36766752
http://dx.doi.org/10.3390/cells12030410

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