Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis

We wished to understand the metabolic reprogramming underlying liver fibrosis progression in mice. Administration to male C57BL/6J mice of the hepatotoxins carbon tetrachloride (CCl4), thioacetamide (TAA), or a 60% high-fat diet, choline-deficient, amino-acid-defined diet (HF-CDAA) was conducted usi...

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Detalles Bibliográficos
Autores principales: Beyoğlu, Diren, Huang, Pinzhu, Skelton-Badlani, Disha, Zong, Christine, Popov, Yury V., Idle, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914390/
https://www.ncbi.nlm.nih.gov/pubmed/36766828
http://dx.doi.org/10.3390/cells12030485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914390/
https://www.ncbi.nlm.nih.gov/pubmed/36766828
http://dx.doi.org/10.3390/cells12030485

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