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The Role of TAR DNA Binding Protein 43 (TDP-43) as a CandiDate Biomarker of Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

Background: TAR DNA-binding protein 43 (TDP-43) aggregation in neuronal cells is recognized as a hallmark of amyotrophic lateral sclerosis (ALS). Although the literature strongly supports the pathogenetic role of TDP-43 in ALS pathogenesis, the role of TDP-43 as a biomarker of ALS is controversial....

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Detalles Bibliográficos
Autores principales: Gambino, Caterina Maria, Ciaccio, Anna Maria, Lo Sasso, Bruna, Giglio, Rosaria Vincenza, Vidali, Matteo, Agnello, Luisa, Ciaccio, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914415/
https://www.ncbi.nlm.nih.gov/pubmed/36766521
http://dx.doi.org/10.3390/diagnostics13030416