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Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity
Monascus red pigments (MRPs), which are a kind of natural colorant produced by Monascus spp., are widely used in the food and health supplements industry but are not very stable during processing and storage. Thus, MRPs were embedded into liposome membranes using a thin-film ultrasonic method to imp...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914458/ https://www.ncbi.nlm.nih.gov/pubmed/36765975 http://dx.doi.org/10.3390/foods12030447 |
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author | Long, Pengcheng Zhu, Lisha Lai, Huafa Xu, Suyin Dong, Xingxing Shao, Yanchun Wang, Liling Cheng, Shuiyuan Liu, Gang He, Jingren He, Yi |
author_facet | Long, Pengcheng Zhu, Lisha Lai, Huafa Xu, Suyin Dong, Xingxing Shao, Yanchun Wang, Liling Cheng, Shuiyuan Liu, Gang He, Jingren He, Yi |
author_sort | Long, Pengcheng |
collection | PubMed |
description | Monascus red pigments (MRPs), which are a kind of natural colorant produced by Monascus spp., are widely used in the food and health supplements industry but are not very stable during processing and storage. Thus, MRPs were embedded into liposome membranes using a thin-film ultrasonic method to improve stability in this study. Monascus red pigments liposomes (MRPL) exhibited spherical unilamellar vesicles (UV) with particle size, polydispersity indexes (PDI), and zeta potential of 20–200 nm, 0.362 ± 0.023, and −42.37 ± 0.21 mV, respectively. pH, thermal, light, metal ion, storage, and in vitro simulated gastrointestinal digestion stability revealed that, compared with free MRPs, liposomes embedding significantly enhanced the stability of MRPs when exposed to adverse environmental conditions. Furthermore, anticancer assay suggested that MRPL exhibited a stronger inhibitory effect on MKN-28 cells by damaging the integrity of cells, with the IC(50) value at 0.57 mg/mL. Overall, MRPLs possess stronger stability in external environment and in vitro simulated digestion with greater anticancer activity, indicating that MRPLs have the potential for promising application in the functional foods and pharmaceutical industries. |
format | Online Article Text |
id | pubmed-9914458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99144582023-02-11 Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity Long, Pengcheng Zhu, Lisha Lai, Huafa Xu, Suyin Dong, Xingxing Shao, Yanchun Wang, Liling Cheng, Shuiyuan Liu, Gang He, Jingren He, Yi Foods Article Monascus red pigments (MRPs), which are a kind of natural colorant produced by Monascus spp., are widely used in the food and health supplements industry but are not very stable during processing and storage. Thus, MRPs were embedded into liposome membranes using a thin-film ultrasonic method to improve stability in this study. Monascus red pigments liposomes (MRPL) exhibited spherical unilamellar vesicles (UV) with particle size, polydispersity indexes (PDI), and zeta potential of 20–200 nm, 0.362 ± 0.023, and −42.37 ± 0.21 mV, respectively. pH, thermal, light, metal ion, storage, and in vitro simulated gastrointestinal digestion stability revealed that, compared with free MRPs, liposomes embedding significantly enhanced the stability of MRPs when exposed to adverse environmental conditions. Furthermore, anticancer assay suggested that MRPL exhibited a stronger inhibitory effect on MKN-28 cells by damaging the integrity of cells, with the IC(50) value at 0.57 mg/mL. Overall, MRPLs possess stronger stability in external environment and in vitro simulated digestion with greater anticancer activity, indicating that MRPLs have the potential for promising application in the functional foods and pharmaceutical industries. MDPI 2023-01-18 /pmc/articles/PMC9914458/ /pubmed/36765975 http://dx.doi.org/10.3390/foods12030447 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Long, Pengcheng Zhu, Lisha Lai, Huafa Xu, Suyin Dong, Xingxing Shao, Yanchun Wang, Liling Cheng, Shuiyuan Liu, Gang He, Jingren He, Yi Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity |
title | Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity |
title_full | Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity |
title_fullStr | Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity |
title_full_unstemmed | Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity |
title_short | Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity |
title_sort | monascus red pigment liposomes: microstructural characteristics, stability, and anticancer activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914458/ https://www.ncbi.nlm.nih.gov/pubmed/36765975 http://dx.doi.org/10.3390/foods12030447 |
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