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Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity

Monascus red pigments (MRPs), which are a kind of natural colorant produced by Monascus spp., are widely used in the food and health supplements industry but are not very stable during processing and storage. Thus, MRPs were embedded into liposome membranes using a thin-film ultrasonic method to imp...

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Autores principales: Long, Pengcheng, Zhu, Lisha, Lai, Huafa, Xu, Suyin, Dong, Xingxing, Shao, Yanchun, Wang, Liling, Cheng, Shuiyuan, Liu, Gang, He, Jingren, He, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914458/
https://www.ncbi.nlm.nih.gov/pubmed/36765975
http://dx.doi.org/10.3390/foods12030447
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author Long, Pengcheng
Zhu, Lisha
Lai, Huafa
Xu, Suyin
Dong, Xingxing
Shao, Yanchun
Wang, Liling
Cheng, Shuiyuan
Liu, Gang
He, Jingren
He, Yi
author_facet Long, Pengcheng
Zhu, Lisha
Lai, Huafa
Xu, Suyin
Dong, Xingxing
Shao, Yanchun
Wang, Liling
Cheng, Shuiyuan
Liu, Gang
He, Jingren
He, Yi
author_sort Long, Pengcheng
collection PubMed
description Monascus red pigments (MRPs), which are a kind of natural colorant produced by Monascus spp., are widely used in the food and health supplements industry but are not very stable during processing and storage. Thus, MRPs were embedded into liposome membranes using a thin-film ultrasonic method to improve stability in this study. Monascus red pigments liposomes (MRPL) exhibited spherical unilamellar vesicles (UV) with particle size, polydispersity indexes (PDI), and zeta potential of 20–200 nm, 0.362 ± 0.023, and −42.37 ± 0.21 mV, respectively. pH, thermal, light, metal ion, storage, and in vitro simulated gastrointestinal digestion stability revealed that, compared with free MRPs, liposomes embedding significantly enhanced the stability of MRPs when exposed to adverse environmental conditions. Furthermore, anticancer assay suggested that MRPL exhibited a stronger inhibitory effect on MKN-28 cells by damaging the integrity of cells, with the IC(50) value at 0.57 mg/mL. Overall, MRPLs possess stronger stability in external environment and in vitro simulated digestion with greater anticancer activity, indicating that MRPLs have the potential for promising application in the functional foods and pharmaceutical industries.
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spelling pubmed-99144582023-02-11 Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity Long, Pengcheng Zhu, Lisha Lai, Huafa Xu, Suyin Dong, Xingxing Shao, Yanchun Wang, Liling Cheng, Shuiyuan Liu, Gang He, Jingren He, Yi Foods Article Monascus red pigments (MRPs), which are a kind of natural colorant produced by Monascus spp., are widely used in the food and health supplements industry but are not very stable during processing and storage. Thus, MRPs were embedded into liposome membranes using a thin-film ultrasonic method to improve stability in this study. Monascus red pigments liposomes (MRPL) exhibited spherical unilamellar vesicles (UV) with particle size, polydispersity indexes (PDI), and zeta potential of 20–200 nm, 0.362 ± 0.023, and −42.37 ± 0.21 mV, respectively. pH, thermal, light, metal ion, storage, and in vitro simulated gastrointestinal digestion stability revealed that, compared with free MRPs, liposomes embedding significantly enhanced the stability of MRPs when exposed to adverse environmental conditions. Furthermore, anticancer assay suggested that MRPL exhibited a stronger inhibitory effect on MKN-28 cells by damaging the integrity of cells, with the IC(50) value at 0.57 mg/mL. Overall, MRPLs possess stronger stability in external environment and in vitro simulated digestion with greater anticancer activity, indicating that MRPLs have the potential for promising application in the functional foods and pharmaceutical industries. MDPI 2023-01-18 /pmc/articles/PMC9914458/ /pubmed/36765975 http://dx.doi.org/10.3390/foods12030447 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Long, Pengcheng
Zhu, Lisha
Lai, Huafa
Xu, Suyin
Dong, Xingxing
Shao, Yanchun
Wang, Liling
Cheng, Shuiyuan
Liu, Gang
He, Jingren
He, Yi
Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity
title Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity
title_full Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity
title_fullStr Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity
title_full_unstemmed Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity
title_short Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity
title_sort monascus red pigment liposomes: microstructural characteristics, stability, and anticancer activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914458/
https://www.ncbi.nlm.nih.gov/pubmed/36765975
http://dx.doi.org/10.3390/foods12030447
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