The Binding of Different Substrate Molecules at the Docking Site and the Active Site of γ-Secretase Can Trigger Toxic Events in Sporadic and Familial Alzheimer’s Disease

Pathogenic changes in γ-secretase activity, along with its response to different drugs, can be affected by changes in the saturation of γ-secretase with its substrate. We analyze the saturation of γ-secretase with its substrate using multiscale molecular dynamics studies. We found that an increase i...

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Detalles Bibliográficos
Autores principales: Svedružić, Željko M., Šendula Jengić, Vesna, Ostojić, Lucija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915333/
https://www.ncbi.nlm.nih.gov/pubmed/36768156
http://dx.doi.org/10.3390/ijms24031835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915333/
https://www.ncbi.nlm.nih.gov/pubmed/36768156
http://dx.doi.org/10.3390/ijms24031835

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