Tregs constrain CD8(+) T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves antitumor immune responses in preclinical studies, clinical development has been hampered by on-target, off-tumor toxicity. Here, we report the development of a tumor-anchored ɑ4-1BB agonist (ɑ4-1BB-LAIR), wh...

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Detalles Bibliográficos
Autores principales: Palmeri, Joseph R., Lax, Brianna M., Peters, Joshua M., Duhamel, Lauren, Stinson, Jordan A., Santollani, Luciano, Lutz, Emi A., Pinney, William, Bryson, Bryan D., Wittrup, K. Dane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915483/
https://www.ncbi.nlm.nih.gov/pubmed/36778460
http://dx.doi.org/10.1101/2023.01.30.526116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915483/
https://www.ncbi.nlm.nih.gov/pubmed/36778460
http://dx.doi.org/10.1101/2023.01.30.526116

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