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Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors
The main risk factor for chronic obstructive pulmonary disease (COPD) is active smoking. However, a considerable amount of people with COPD never smoked, and increasing evidence suggests that adult lung disease can have its origins in prenatal and early life. This article reviews some of the factors...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915555/ https://www.ncbi.nlm.nih.gov/pubmed/36767660 http://dx.doi.org/10.3390/ijerph20032294 |
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author | Deolmi, Michela Decarolis, Nicola Mattia Motta, Matteo Makrinioti, Heidi Fainardi, Valentina Pisi, Giovanna Esposito, Susanna |
author_facet | Deolmi, Michela Decarolis, Nicola Mattia Motta, Matteo Makrinioti, Heidi Fainardi, Valentina Pisi, Giovanna Esposito, Susanna |
author_sort | Deolmi, Michela |
collection | PubMed |
description | The main risk factor for chronic obstructive pulmonary disease (COPD) is active smoking. However, a considerable amount of people with COPD never smoked, and increasing evidence suggests that adult lung disease can have its origins in prenatal and early life. This article reviews some of the factors that can potentially affect lung development and lung function trajectories throughout the lifespan from genetics and prematurity to respiratory tract infections and childhood asthma. Maternal smoking and air pollution exposure were also analyzed among the environmental factors. The adoption of preventive strategies to avoid these risk factors since the prenatal period may be crucial to prevent, delay the onset or modify the progression of COPD lung disease throughout life. |
format | Online Article Text |
id | pubmed-9915555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99155552023-02-11 Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors Deolmi, Michela Decarolis, Nicola Mattia Motta, Matteo Makrinioti, Heidi Fainardi, Valentina Pisi, Giovanna Esposito, Susanna Int J Environ Res Public Health Review The main risk factor for chronic obstructive pulmonary disease (COPD) is active smoking. However, a considerable amount of people with COPD never smoked, and increasing evidence suggests that adult lung disease can have its origins in prenatal and early life. This article reviews some of the factors that can potentially affect lung development and lung function trajectories throughout the lifespan from genetics and prematurity to respiratory tract infections and childhood asthma. Maternal smoking and air pollution exposure were also analyzed among the environmental factors. The adoption of preventive strategies to avoid these risk factors since the prenatal period may be crucial to prevent, delay the onset or modify the progression of COPD lung disease throughout life. MDPI 2023-01-27 /pmc/articles/PMC9915555/ /pubmed/36767660 http://dx.doi.org/10.3390/ijerph20032294 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Deolmi, Michela Decarolis, Nicola Mattia Motta, Matteo Makrinioti, Heidi Fainardi, Valentina Pisi, Giovanna Esposito, Susanna Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors |
title | Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors |
title_full | Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors |
title_fullStr | Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors |
title_full_unstemmed | Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors |
title_short | Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors |
title_sort | early origins of chronic obstructive pulmonary disease: prenatal and early life risk factors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915555/ https://www.ncbi.nlm.nih.gov/pubmed/36767660 http://dx.doi.org/10.3390/ijerph20032294 |
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