Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy

Myotonic dystrophy is a multisystemic neuromuscular disease caused by either a CTG repeat expansion in DMPK (DM1) or a CCTG repeat expansion in CNBP (DM2). Transcription of the expanded alleles produces toxic gain-of-function RNA that sequester the MBNL family of alternative splicing regulators into...

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Detalles Bibliográficos
Autores principales: Mishra, Subodh K., Hicks, Sawyer M., Frias, Jesus A., Vangaveti, Sweta, Nakamori, Masayuki, Cleary, John D., Reddy, Kaalak, Berglund, J. Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915578/
https://www.ncbi.nlm.nih.gov/pubmed/36778282
http://dx.doi.org/10.1101/2023.02.02.526846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915578/
https://www.ncbi.nlm.nih.gov/pubmed/36778282
http://dx.doi.org/10.1101/2023.02.02.526846

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