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Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy

Myotonic dystrophy is a multisystemic neuromuscular disease caused by either a CTG repeat expansion in DMPK (DM1) or a CCTG repeat expansion in CNBP (DM2). Transcription of the expanded alleles produces toxic gain-of-function RNA that sequester the MBNL family of alternative splicing regulators into...

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Detalles Bibliográficos
Autores principales:	Mishra, Subodh K., Hicks, Sawyer M., Frias, Jesus A., Vangaveti, Sweta, Nakamori, Masayuki, Cleary, John D., Reddy, Kaalak, Berglund, J. Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915578/ https://www.ncbi.nlm.nih.gov/pubmed/36778282 http://dx.doi.org/10.1101/2023.02.02.526846

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