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Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases
5-Methylcytosine (5mC) and DNA methyltransferases (DNMTs) are broadly conserved in eukaryotes but are also frequently lost during evolution. The mammalian SNF2 family ATPase HELLS and its plant ortholog DDM1 are critical for maintaining 5mC. Mutations in HELLS, its activator CDCA7, and the de novo D...
Autores principales: | Funabiki, Hironori, Wassing, Isabel E., Jia, Qingyuan, Luo, Ji-Dung, Carroll, Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915587/ https://www.ncbi.nlm.nih.gov/pubmed/36778482 http://dx.doi.org/10.1101/2023.01.30.526367 |
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