tRNA m(1)G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10

The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the 9th nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya and Archaea, and mutations in the human gene (TRMT10A) have been linked to neurological disorders such as microcephaly and intellectual disabil...

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Detalles Bibliográficos
Autores principales: Strassler, Sarah E., Bowles, Isobel E., Krishnamohan, Aiswarya, Kim, Hyejeong, Edgington, Catherine B., Kuiper, Emily G., Hancock, Clio J., Comstock, Lindsay R., Jackman, Jane E., Conn, Graeme L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915607/
https://www.ncbi.nlm.nih.gov/pubmed/36778341
http://dx.doi.org/10.1101/2023.02.01.526536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915607/
https://www.ncbi.nlm.nih.gov/pubmed/36778341
http://dx.doi.org/10.1101/2023.02.01.526536

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