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Single-cell multi-omic topic embedding reveals cell-type-specific and COVID-19 severity-related immune signatures

The advent of single-cell multi-omics sequencing technology makes it possible for researchers to leverage multiple modalities for individual cells and explore cell heterogeneity. However, the high dimensional, discrete, and sparse nature of the data make the downstream analysis particularly challeng...

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Detalles Bibliográficos
Autores principales: Zhou, Manqi, Zhang, Hao, Baii, Zilong, Mann-Krzisnik, Dylan, Wang, Fei, Li, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915637/
https://www.ncbi.nlm.nih.gov/pubmed/36778483
http://dx.doi.org/10.1101/2023.01.31.526312