Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT)

Aging muscle experiences functional decline in part mediated by impaired mitochondrial ADP sensitivity. Elamipretide (ELAM) rapidly improves physiological and mitochondrial function in aging and binds directly to the mitochondrial ADP transporter ANT. We hypothesized that ELAM improves ADP sensitivi...

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Detalles Bibliográficos
Autores principales: Pharaoh, Gavin, Kamat, Varun, Kannan, Sricharan, Stuppard, Rudolph S., Whitson, Jeremy, Martin-Perez, Miguel, Qian, Wei-Jun, MacCoss, Michael J., Villen, Judit, Rabinovitch, Peter, Campbell, Matthew D., Sweet, Ian R., Marcinek, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915686/
https://www.ncbi.nlm.nih.gov/pubmed/36778398
http://dx.doi.org/10.1101/2023.02.01.525989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915686/
https://www.ncbi.nlm.nih.gov/pubmed/36778398
http://dx.doi.org/10.1101/2023.02.01.525989

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