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Systematic conformation-to-phenotype mapping via limited deep-sequencing of proteins

Non-native conformations drive protein misfolding diseases, complicate bioengineering efforts, and fuel molecular evolution. No current experimental technique is well-suited for elucidating them and their phenotypic effects. Especially intractable are the transient conformations populated by intrins...

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Detalles Bibliográficos
Autores principales: Serebryany, Eugene, Zhao, Victor Y., Park, Kibum, Bitran, Amir, Trauger, Sunia A., Budnik, Bogdan, Shakhnovich, Eugene I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cornell University 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915745/
https://www.ncbi.nlm.nih.gov/pubmed/36776823