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Systematic conformation-to-phenotype mapping via limited deep-sequencing of proteins
Non-native conformations drive protein misfolding diseases, complicate bioengineering efforts, and fuel molecular evolution. No current experimental technique is well-suited for elucidating them and their phenotypic effects. Especially intractable are the transient conformations populated by intrins...
Autores principales: | Serebryany, Eugene, Zhao, Victor Y., Park, Kibum, Bitran, Amir, Trauger, Sunia A., Budnik, Bogdan, Shakhnovich, Eugene I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cornell University
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915745/ https://www.ncbi.nlm.nih.gov/pubmed/36776823 |
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