Cargando…

A de novo missense variant in EZH1 associated with developmental delay exhibits functional deficits in Drosophila melanogaster

EZH1 (Enhancer of Zeste, homolog 1), a Polycomb Repressive Complex-2 (PRC2) component, is involved in a myriad of cellular processes through modifying histone 3 lysine27 (H3K27) residues. EZH1 represses transcription of downstream target genes through H3K27 trimethylation (H3K27me3). Genetic mutatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Jangam, Sharayu, Briere, Lauren C., Jay, Kristy, Andrews, Jonathan C, Walker, Melissa A., Rodan, Lance H., High, Frances A., Yamamoto, Shinya, Sweetser, David A., Wangler, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915809/
https://www.ncbi.nlm.nih.gov/pubmed/36778246
http://dx.doi.org/10.1101/2023.01.31.23285113