Cargando…

Gliflozins Have an Anti-Inflammatory Effect on Renal Proximal Tubular Epithelial Cells in a Diabetic and Inflammatory Microenvironment In Vitro

Inflammation is intimately involved in the pathogenesis of diabetic kidney disease. Inhibition of SGLT-2 by a specific class of drugs, gliflozins, has been shown to reduce inflammation and attenuate the progression of diabetic nephropathy, in addition to its main effect of inhibiting renal glucose r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koch, Benjamin, Fuhrmann, Dominik C., Schubert, Ralf, Geiger, Helmut, Speer, Thimoteus, Baer, Patrick C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916320/ https://www.ncbi.nlm.nih.gov/pubmed/36768138 http://dx.doi.org/10.3390/ijms24031811

Ejemplares similares

No Cytotoxic and Inflammatory Effects of Empagliflozin and Dapagliflozin on Primary Renal Proximal Tubular Epithelial Cells under Diabetic Conditions In Vitro
por: Baer, Patrick C., et al.
Publicado: (2020)

microRNA Expression of Renal Proximal Tubular Epithelial Cells and Their Extracellular Vesicles in an Inflammatory Microenvironment In Vitro
por: Baer, Patrick C., et al.
Publicado: (2023)

Gliflozine – in Zukunft Kardioprotektiva?
por: Rauch-Kröhnert, Ursula, et al.
Publicado: (2021)

Characterization of Extracellular Vesicles from Preconditioned Human Adipose-Derived Stromal/Stem Cells
por: Geßner, Alec, et al.
Publicado: (2021)

Selecting Patients at Risk of Developing DKA on Gliflozins
por: Maletkovic, Jelena
Publicado: (2021)

Cardiovascular Benefits from Gliflozins: Effects on Endothelial Function
por: Salvatore, Teresa, et al.
Publicado: (2021)

Gliflozins, Erythropoietin, and Erythrocytosis: Is It Renal Normoxia- or Hypoxia-Driven?
por: Heyman, Samuel N., et al.
Publicado: (2023)

Tissue Kallikrein Mediates Pro-Inflammatory Pathways and Activation of Protease-Activated Receptor-4 in Proximal Tubular Epithelial Cells
por: Yiu, Wai Han, et al.
Publicado: (2014)

Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8(+) T Cells
por: Linke, Alexandra, et al.
Publicado: (2022)

Therapy of Type 2 diabetes: more gliflozines and less metformin?
por: Verdecchia, Paolo, et al.
Publicado: (2023)

Case Report: Multisystem inflammatory syndrome in children with associated proximal tubular injury
por: Orsi, Silvia Maria, et al.
Publicado: (2023)

Surprises in cardiology: efficacy of gliflozines in heart failure even in the absence of diabetes
por: Bragagni, Alessio, et al.
Publicado: (2021)

Effects of Hypoxia on RNA Cargo in Extracellular Vesicles from Human Adipose-Derived Stromal/Stem Cells
por: Koch, Benjamin, et al.
Publicado: (2022)

Motile Cilia on Kidney Proximal Tubular Epithelial Cells Are Associated With Tubular Injury and Interstitial Fibrosis
por: Eymael, Jennifer, et al.
Publicado: (2022)

Mitochondrial Dynamics of Proximal Tubular Epithelial Cells in Nephropathic Cystinosis
por: De Rasmo, Domenico, et al.
Publicado: (2019)

Expression of immunoglobulin G in human proximal tubular epithelial cells
por: Deng, Zhenling, et al.
Publicado: (2021)

Isolation, Characterization, Differentiation and Immunomodulatory Capacity of Mesenchymal Stromal/Stem Cells from Human Perirenal Adipose Tissue
por: Baer, Patrick C., et al.
Publicado: (2019)

Single‐cell RNA landscape of cell fate decision of renal proximal tubular epithelial cells and immune‐microenvironment in kidney fibrosis
por: Zhu, Minyan, et al.
Publicado: (2022)

Empagliflozin Inhibits IL-1β-Mediated Inflammatory Response in Human Proximal Tubular Cells
por: Pirklbauer, Markus, et al.
Publicado: (2021)

Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair
por: Ide, Shintaro, et al.
Publicado: (2021)

Effect of Different Preconditioning Regimens on the Expression Profile of Murine Adipose-Derived Stromal/Stem Cells
por: Baer, Patrick C., et al.
Publicado: (2018)

Budget Impact Analysis of Expanding Gliflozin Coverage in the CKD Population: A French Perspective
por: de Pouvourville, Gérard, et al.
Publicado: (2023)

MIR210HG Aggravates Sepsis-Induced Inflammatory Response of Proximal Tubular Epithelial Cell via the NF-κB Signaling Pathway
por: Deng, Shuai, et al.
Publicado: (2021)

Nicotine-Induced Apoptosis in Human Renal Proximal Tubular Epithelial Cells
por: Kim, Chang Seong, et al.
Publicado: (2016)

Anti-inflammatory and anti-apoptotic effects of paricalcitol in lipopolysaccharide-induced renal proximal tubular cell injury
por: Kim, Soo Wan
Publicado: (2017)

SAVOR-TIMI to DECLARE-TIMI: A Review on Cardiovascular Outcome Trials of Incretin-modulators and Gliflozins
por: Singh, Awadhesh K., et al.
Publicado: (2019)

Gliflozins for the prevention of stroke in diabetes and cardiorenal diseases: A meta-analysis of cardiovascular outcome trials
por: Zhao, Li-Min, et al.
Publicado: (2021)

Inflammatory loops in the epithelial–immune microenvironment of the skin and skin appendages in chronic inflammatory diseases
por: Dainichi, Teruki, et al.
Publicado: (2023)

Tracking of Adipose-Derived Mesenchymal Stromal/Stem Cells in a Model of Cisplatin-Induced Acute Kidney Injury: Comparison of Bioluminescence Imaging versus qRT-PCR
por: Schubert, Ralf, et al.
Publicado: (2018)

TRPM7 promotes lipopolysaccharide‐induced inflammatory dysfunction in renal tubular epithelial cells
por: Sun, Yan, et al.
Publicado: (2022)

Kidney Inflammation, Injury and Regeneration
por: Baer, Patrick C., et al.
Publicado: (2020)

Kidney Inflammation, Injury and Regeneration 2020
por: Baer, Patrick C., et al.
Publicado: (2021)

High Glucose Increases Metallothionein Expression in Renal Proximal Tubular Epithelial Cells
por: Ogawa, Daisuke, et al.
Publicado: (2011)

NLRP2 Regulates Proinflammatory and Antiapoptotic Responses in Proximal Tubular Epithelial Cells
por: Rossi, Marianna N., et al.
Publicado: (2019)

Adenine overload induces ferroptosis in human primary proximal tubular epithelial cells
por: Khan, Muhammad Ali, et al.
Publicado: (2022)

Cardiovascular outcomes associated with canagliflozin versus other non-gliflozin antidiabetic drugs: population based cohort study
por: Patorno, Elisabetta, et al.
Publicado: (2018)

Molecular and functional profiling of apical versus basolateral small extracellular vesicles derived from primary human proximal tubular epithelial cells under inflammatory conditions
por: Wang, Xiangju, et al.
Publicado: (2021)

Proximal Tubular Hypertrophy and Enlarged Glomerular and Proximal Tubular Urinary Space in Obese Subjects with Proteinuria
por: Tobar, Ana, et al.
Publicado: (2013)

Meta-analyzing the factors affecting the efficacy of gliflozins in patients with heart failure based on heart failure trials
por: Yin, Daogen, et al.
Publicado: (2021)

Rationale and design of the Biventricular Evaluation of Gliflozins effects In chroNic Heart Failure: BEGIN‐HF study
por: Correale, Michele, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_65rk0qtj4np3ggi9p6oa23q5j6