Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer’s Disease

Proteolytic processing of amyloid precursor protein (APP) plays a critical role in pathogenesis of Azheimer’s disease (AD). Sequential cleavage of APP by β- and γ-secretases leads to generation of Aβ40 (non-amyloidogenic) and Aβ42 (amyloidogenic) peptides. Presenilin-1 (PS1) or presenilin-2 (PS2) ac...

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Detalles Bibliográficos
Autores principales: Kim, Meewhi, Bezprozvanny, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Concept Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916408/
https://www.ncbi.nlm.nih.gov/pubmed/36768421
http://dx.doi.org/10.3390/ijms24032092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916408/
https://www.ncbi.nlm.nih.gov/pubmed/36768421
http://dx.doi.org/10.3390/ijms24032092

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