Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification

Vascular calcification (VC) is an important contributor and prognostic factor in the pathogenesis of cardiovascular diseases. VC is an active process mediated by the release of extracellular vesicles by vascular smooth muscle cells (VSMCs), and the enzyme neutral sphingomyelinase 2 (nSMase2 or SMPD3...

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Detalles Bibliográficos
Autores principales: Pavlic, Angelina, Poelman, Hessel, Wasilewski, Grzegorz, Wichapong, Kanin, Lux, Petra, Maassen, Cecile, Lutgens, Esther, Schurgers, Leon J., Reutelingsperger, Chris P., Nicolaes, Gerry A. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916533/
https://www.ncbi.nlm.nih.gov/pubmed/36768348
http://dx.doi.org/10.3390/ijms24032027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916533/
https://www.ncbi.nlm.nih.gov/pubmed/36768348
http://dx.doi.org/10.3390/ijms24032027

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