Splicing Modulation Results in Aberrant Isoforms and Protein Products of p53 Pathway Genes and the Sensitization of B Cells to Non-Genotoxic MDM2 Inhibition

Several molecular subtypes of cancer are highly dependent on splicing for cell survival. There is a general interest in the therapeutic targeting of splicing by small molecules. E7107, a first-in-class spliceosome inhibitor, showed strong growth inhibitory activities against a large variety of human...

Descripción completa

Detalles Bibliográficos
Autores principales: Aptullahoglu, Erhan, Ciardullo, Carmela, Wallis, Jonathan P., Marr, Helen, Marshall, Scott, Bown, Nick, Willmore, Elaine, Lunec, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916657/
https://www.ncbi.nlm.nih.gov/pubmed/36768733
http://dx.doi.org/10.3390/ijms24032410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916657/
https://www.ncbi.nlm.nih.gov/pubmed/36768733
http://dx.doi.org/10.3390/ijms24032410

Ejemplares similares