Attenuation of Tumor Burden in Response to Rucaparib in Lung Adenocarcinoma: The Contribution of Oxidative Stress, Apoptosis, and DNA Damage

In cancer, overactivation of poly (ADPribose) polymerases (PARP) plays a relevant role in DNA repair. We hypothesized that treatment with the PARP inhibitor rucaparib may reduce tumor burden via several biological mechanisms (apoptosis and oxidative stress) in mice. In lung tumors (LP07 lung adenoca...

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Detalles Bibliográficos
Autores principales: Pérez-Peiró, Maria, Valentí-Serra, Paula, León-González, Blanca, Ampurdanés, Coral, Duran, Xavier, Yélamos, José, Barreiro, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916668/
https://www.ncbi.nlm.nih.gov/pubmed/36768904
http://dx.doi.org/10.3390/ijms24032580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916668/
https://www.ncbi.nlm.nih.gov/pubmed/36768904
http://dx.doi.org/10.3390/ijms24032580

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