Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease

A series of previously synthesized conjugates of tacrine and salicylamide was extended by varying the structure of the salicylamide fragment and using salicylic aldehyde to synthesize salicylimine derivatives. The hybrids exhibited broad-spectrum biological activity. All new conjugates were potent i...

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Detalles Bibliográficos
Autores principales: Makhaeva, Galina F., Kovaleva, Nadezhda V., Rudakova, Elena V., Boltneva, Natalia P., Grishchenko, Maria V., Lushchekina, Sofya V., Astakhova, Tatiana Y., Serebryakova, Olga G., Timokhina, Elena N., Zhilina, Ekaterina F., Shchegolkov, Evgeny V., Ulitko, Mariya V., Radchenko, Eugene V., Palyulin, Vladimir A., Burgart, Yanina V., Saloutin, Victor I., Bachurin, Sergey O., Richardson, Rudy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916969/
https://www.ncbi.nlm.nih.gov/pubmed/36768608
http://dx.doi.org/10.3390/ijms24032285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916969/
https://www.ncbi.nlm.nih.gov/pubmed/36768608
http://dx.doi.org/10.3390/ijms24032285

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