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Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease
A series of previously synthesized conjugates of tacrine and salicylamide was extended by varying the structure of the salicylamide fragment and using salicylic aldehyde to synthesize salicylimine derivatives. The hybrids exhibited broad-spectrum biological activity. All new conjugates were potent i...
Autores principales: | Makhaeva, Galina F., Kovaleva, Nadezhda V., Rudakova, Elena V., Boltneva, Natalia P., Grishchenko, Maria V., Lushchekina, Sofya V., Astakhova, Tatiana Y., Serebryakova, Olga G., Timokhina, Elena N., Zhilina, Ekaterina F., Shchegolkov, Evgeny V., Ulitko, Mariya V., Radchenko, Eugene V., Palyulin, Vladimir A., Burgart, Yanina V., Saloutin, Victor I., Bachurin, Sergey O., Richardson, Rudy J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916969/ https://www.ncbi.nlm.nih.gov/pubmed/36768608 http://dx.doi.org/10.3390/ijms24032285 |
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