Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer’s Disease-Related Pathologies

We previously demonstrated that the Alzheimer’s disease (AD)-like model mice, Tg2576, housed at a high ambient temperature of 30 °C for 13 months, exhibited increased body temperature, which increased amyloid-β (Aβ) levels and tau stability, leading to tau phosphorylation and ultimately inducing mem...

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Detalles Bibliográficos
Autores principales: Jung, Cha-Gyun, Yamashita, Hitoshi, Kato, Reiko, Zhou, Chunyu, Matsushita, Hiroaki, Takeuchi, Tamaki, Abdelhamid, Mona, Chen, Yuxin, Michikawa, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917061/
https://www.ncbi.nlm.nih.gov/pubmed/36769062
http://dx.doi.org/10.3390/ijms24032741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917061/
https://www.ncbi.nlm.nih.gov/pubmed/36769062
http://dx.doi.org/10.3390/ijms24032741

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