Fusion of Wild-Type Mesoangioblasts with Myotubes of mtDNA Mutation Carriers Leads to a Proportional Reduction in mtDNA Mutation Load

In 25% of patients with mitochondrial myopathies, pathogenic mitochondrial DNA (mtDNA) mutation are the cause. For heteroplasmic mtDNA mutations, symptoms manifest when the mutation load exceeds a tissue-specific threshold. Therefore, lowering the mutation load is expected to ameliorate disease mani...

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Detalles Bibliográficos
Autores principales: Zelissen, Ruby, Ahmadian, Somaieh, Montilla-Rojo, Joaquin, Timmer, Erika, Ummelen, Monique, Hopman, Anton, Smeets, Hubert, van Tienen, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917062/
https://www.ncbi.nlm.nih.gov/pubmed/36769001
http://dx.doi.org/10.3390/ijms24032679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917062/
https://www.ncbi.nlm.nih.gov/pubmed/36769001
http://dx.doi.org/10.3390/ijms24032679

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