Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null Mice

Obesity is a risk factor for preeclampsia. We investigated how obesity influences preeclampsia in mice lacking ankyrin-repeat-and-SOCS-box-containing-protein 4 (ASB4), which promotes trophoblast differentiation via degrading the inhibitor of DNA-binding protein 2 (ID2). Asb4(−/−) mice on normal chow...

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Detalles Bibliográficos
Autores principales: Kayashima, Yukako, Townley-Tilson, W. H. Davin, Vora, Neeta L., Boggess, Kim, Homeister, Jonathon W., Maeda-Smithies, Nobuyo, Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917068/
https://www.ncbi.nlm.nih.gov/pubmed/36768469
http://dx.doi.org/10.3390/ijms24032149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917068/
https://www.ncbi.nlm.nih.gov/pubmed/36768469
http://dx.doi.org/10.3390/ijms24032149

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