Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil

Leiomyomas (LMs) are the most frequent uterine benign tumors, representing the leading cause of hysterectomy indications worldwide. They are highly associated with women’s reproductive complications, and endocrine disruptors may influence their etiology. In this sense, air pollution represents a rel...

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Autores principales: dos Anjos, Laura Gonzalez, de Almeida, Bruna Cristine, Baracat, Edmund Chada, Al-Hendy, Ayman, Yang, Qiwei, Carvalho, Katia Candido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917088/
https://www.ncbi.nlm.nih.gov/pubmed/36768749
http://dx.doi.org/10.3390/ijms24032431
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author dos Anjos, Laura Gonzalez
de Almeida, Bruna Cristine
Baracat, Edmund Chada
Al-Hendy, Ayman
Yang, Qiwei
Carvalho, Katia Candido
author_facet dos Anjos, Laura Gonzalez
de Almeida, Bruna Cristine
Baracat, Edmund Chada
Al-Hendy, Ayman
Yang, Qiwei
Carvalho, Katia Candido
author_sort dos Anjos, Laura Gonzalez
collection PubMed
description Leiomyomas (LMs) are the most frequent uterine benign tumors, representing the leading cause of hysterectomy indications worldwide. They are highly associated with women’s reproductive complications, and endocrine disruptors may influence their etiology. In this sense, air pollution represents a relevant hormonal disruptor that acts on key signaling pathways, resulting in tumor development and infertility. Our goal was to evaluate submucosal LM samples from patients living in the metropolitan and Sao Paulo city regions, focusing on genes involved in tumor development and infertility features. Twenty-four patients were selected based on their region of residence and clinical information availability. Several genes were differentially expressed between women living in metropolitan areas and Sao Paulo city. Significant associations were observed between BCL-2, DVL1, FGFR3, and WNT5b downregulation and contraceptive use in the samples from women living in Sao Paulo city. ESR1 and HHAT downregulation was associated with ethnicity. WNT5b and GREM were associated with LM treatment and related pathologies, respectively. In the samples from women living in other cities of the metropolitan region, abortion occurrence was associated with BMP4 upregulation. Although further studies may be necessary, our results showed that air pollution exposure influences the expression of genes related to LM development and female reproductive features.
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spelling pubmed-99170882023-02-11 Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil dos Anjos, Laura Gonzalez de Almeida, Bruna Cristine Baracat, Edmund Chada Al-Hendy, Ayman Yang, Qiwei Carvalho, Katia Candido Int J Mol Sci Article Leiomyomas (LMs) are the most frequent uterine benign tumors, representing the leading cause of hysterectomy indications worldwide. They are highly associated with women’s reproductive complications, and endocrine disruptors may influence their etiology. In this sense, air pollution represents a relevant hormonal disruptor that acts on key signaling pathways, resulting in tumor development and infertility. Our goal was to evaluate submucosal LM samples from patients living in the metropolitan and Sao Paulo city regions, focusing on genes involved in tumor development and infertility features. Twenty-four patients were selected based on their region of residence and clinical information availability. Several genes were differentially expressed between women living in metropolitan areas and Sao Paulo city. Significant associations were observed between BCL-2, DVL1, FGFR3, and WNT5b downregulation and contraceptive use in the samples from women living in Sao Paulo city. ESR1 and HHAT downregulation was associated with ethnicity. WNT5b and GREM were associated with LM treatment and related pathologies, respectively. In the samples from women living in other cities of the metropolitan region, abortion occurrence was associated with BMP4 upregulation. Although further studies may be necessary, our results showed that air pollution exposure influences the expression of genes related to LM development and female reproductive features. MDPI 2023-01-26 /pmc/articles/PMC9917088/ /pubmed/36768749 http://dx.doi.org/10.3390/ijms24032431 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
dos Anjos, Laura Gonzalez
de Almeida, Bruna Cristine
Baracat, Edmund Chada
Al-Hendy, Ayman
Yang, Qiwei
Carvalho, Katia Candido
Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil
title Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil
title_full Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil
title_fullStr Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil
title_full_unstemmed Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil
title_short Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil
title_sort gene expression profile of uterine leiomyoma from women exposed to different air pollution levels in metropolitan cities of sao paulo, brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917088/
https://www.ncbi.nlm.nih.gov/pubmed/36768749
http://dx.doi.org/10.3390/ijms24032431
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