PCSK9 Inhibitors Have Apolipoprotein C-III-Related Anti-Inflammatory Activity, Assessed by 1H-NMR Glycoprotein Profile in Subjects at High or very High Cardiovascular Risk

HIGHLIGHTS: What are the main findings? PCSK9 inhibition significantly reduces 1H-NMR glycoprotein signals and does not affect hsCRP levels. Apolipoprotein C-III and triglycerides are also decreased by iPCSK9. The decrease in glycoproteins correlates with the decrease in apoC-III and TG. What is the...

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Detalles Bibliográficos
Autores principales: Rehues, Pere, Girona, Josefa, Guardiola, Montse, Plana, Núria, Scicali, Roberto, Piro, Salvatore, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, José Luis, Recasens, Lluís, Pinyol, Marta, Rosales, Roser, Esteban, Yaiza, Amigó, Núria, Masana, Lluís, Ibarretxe, Daiana, Ribalta, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917120/
https://www.ncbi.nlm.nih.gov/pubmed/36768645
http://dx.doi.org/10.3390/ijms24032319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917120/
https://www.ncbi.nlm.nih.gov/pubmed/36768645
http://dx.doi.org/10.3390/ijms24032319

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