In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part III

The development of in vitro/in vivo translational methods and a clinical trial framework for synergistically acting drug combinations are needed to identify optimal therapeutic conditions with the most effective therapeutic strategies. We performed physiologically based pharmacokinetic–pharmacodynam...

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Detalles Bibliográficos
Autores principales: Witkowski, Jakub, Polak, Sebastian, Pawelec, Dariusz, Rogulski, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917191/
https://www.ncbi.nlm.nih.gov/pubmed/36768563
http://dx.doi.org/10.3390/ijms24032239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917191/
https://www.ncbi.nlm.nih.gov/pubmed/36768563
http://dx.doi.org/10.3390/ijms24032239

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