Expression of the Z Variant of α1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic Zebrafish

Individuals homozygous for the Pi*Z allele of SERPINA1 (ZAAT) are susceptible to lung disease due to insufficient α1-antitrypsin secretion into the circulation and may develop liver disease due to compromised protein folding that leads to inclusion body formation in the endoplasmic reticulum (ER) of...

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Detalles Bibliográficos
Autores principales: Fung, Connie, Wilding, Brendan, Schittenhelm, Ralf B., Bryson-Richardson, Robert J., Bird, Phillip I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917206/
https://www.ncbi.nlm.nih.gov/pubmed/36768797
http://dx.doi.org/10.3390/ijms24032475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917206/
https://www.ncbi.nlm.nih.gov/pubmed/36768797
http://dx.doi.org/10.3390/ijms24032475

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