Knockdown of Amyloid Precursor Protein Increases Ion Channel Expression and Alters Ca(2+) Signaling Pathways

Although the physiological role of the full-length Amyloid Precursor Protein (APP) and its proteolytic fragments remains unclear, they are definitively crucial for normal synaptic function. Herein, we report that the downregulation of APP in SH-SY5Y cells, using short hairpin RNA (shRNA), alters the...

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Detalles Bibliográficos
Autores principales: Paschou, Maria, Liaropoulou, Danai, Kalaitzaki, Vasileia, Efthimiopoulos, Spiros, Papazafiri, Panagiota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917207/
https://www.ncbi.nlm.nih.gov/pubmed/36768625
http://dx.doi.org/10.3390/ijms24032302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917207/
https://www.ncbi.nlm.nih.gov/pubmed/36768625
http://dx.doi.org/10.3390/ijms24032302

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