Androgen Deprivation Freezes Hormone-Sensitive Prostate Cancer Cells in a Reversible, Genetically Unstable Quasi-Apoptotic State, Bursting into Full Apoptosis upon Poly(ADP-ribose) Polymerase Inhibition

Androgen deprivation therapy (ADT) is a powerful treatment for metastatic hormone-sensitive prostate cancer (mHSPC) patients, but eventually and inevitably, cancer relapses, progressing to the fatal castration-resistant (CR)PC stage. Progression implies the emergence of cells proliferating in the ab...

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Detalles Bibliográficos
Autores principales: Pelliccia, Andrea, Capradossi, Francesco, Corsi, Francesca, Tarquini, Greta Deidda, Bruni, Emanuele, Reichle, Albrecht, Torino, Francesco, Ghibelli, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917232/
https://www.ncbi.nlm.nih.gov/pubmed/36768364
http://dx.doi.org/10.3390/ijms24032040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917232/
https://www.ncbi.nlm.nih.gov/pubmed/36768364
http://dx.doi.org/10.3390/ijms24032040

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