Crystal Structure of Inhibitor-Bound Bacterial Oligopeptidase B in the Closed State: Similarity and Difference between Protozoan and Bacterial Enzymes

The crystal structure of bacterial oligopeptidase B from Serratia proteamaculans (SpOpB) in complex with a chloromethyl ketone inhibitor was determined at 2.2 Å resolution. SpOpB was crystallized in a closed (catalytically active) conformation. A single inhibitor molecule bound simultaneously to the...

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Detalles Bibliográficos
Autores principales: Petrenko, Dmitry E., Karlinsky, David M., Gordeeva, Veronika D., Arapidi, Georgij P., Britikova, Elena V., Britikov, Vladimir V., Nikolaeva, Alena Y., Boyko, Konstantin M., Timofeev, Vladimir I., Kuranova, Inna P., Mikhailova, Anna G., Bocharov, Eduard V., Rakitina, Tatiana V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917282/
https://www.ncbi.nlm.nih.gov/pubmed/36768612
http://dx.doi.org/10.3390/ijms24032286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917282/
https://www.ncbi.nlm.nih.gov/pubmed/36768612
http://dx.doi.org/10.3390/ijms24032286

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