Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinction

The phenotypic efficacy of somatic copy number alterations (SCNAs) stems from their incidence per base pair of the genome, which is orders of magnitudes greater than that of point mutations. One mitotic event stands out in its potential to significantly change a cell’s SCNA burden–a chromosome misse...

Descripción completa

Detalles Bibliográficos
Autores principales: Kimmel, Gregory J., Beck, Richard J., Yu, Xiaoqing, Veith, Thomas, Bakhoum, Samuel, Altrock, Philipp M., Andor, Noemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917311/
https://www.ncbi.nlm.nih.gov/pubmed/36689467
http://dx.doi.org/10.1371/journal.pcbi.1010815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917311/
https://www.ncbi.nlm.nih.gov/pubmed/36689467
http://dx.doi.org/10.1371/journal.pcbi.1010815

Ejemplares similares