N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

Dystroglycan (DG) requires extensive post-translational processing and O-glycosylation to function as a receptor for extracellular matrix (ECM) proteins containing laminin-G (LG) domains. Matriglycan is an elongated polysaccharide of alternating xylose (Xyl) and glucuronic acid (GlcA) that binds wit...

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Detalles Bibliográficos
Autores principales: Okuma, Hidehiko, Hord, Jeffrey M, Chandel, Ishita, Venzke, David, Anderson, Mary E, Walimbe, Ameya S, Joseph, Soumya, Gastel, Zeita, Hara, Yuji, Saito, Fumiaki, Matsumura, Kiichiro, Campbell, Kevin P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917425/
https://www.ncbi.nlm.nih.gov/pubmed/36723429
http://dx.doi.org/10.7554/eLife.82811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917425/
https://www.ncbi.nlm.nih.gov/pubmed/36723429
http://dx.doi.org/10.7554/eLife.82811

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