Nucleotide binding is the critical regulator of ABCG2 conformational transitions

ABCG2 is an exporter-type ABC protein that can expel numerous chemically unrelated xeno- and endobiotics from cells. When expressed in tumor cells or tumor stem cells, ABCG2 confers multidrug resistance, contributing to the failure of chemotherapy. Molecular details orchestrating substrate transloca...

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Detalles Bibliográficos
Autores principales: Gyöngy, Zsuzsanna, Mocsár, Gábor, Hegedűs, Éva, Stockner, Thomas, Ritter, Zsuzsanna, Homolya, László, Schamberger, Anita, Orbán, Tamás I, Remenyik, Judit, Szakacs, Gergely, Goda, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917445/
https://www.ncbi.nlm.nih.gov/pubmed/36763413
http://dx.doi.org/10.7554/eLife.83976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917445/
https://www.ncbi.nlm.nih.gov/pubmed/36763413
http://dx.doi.org/10.7554/eLife.83976

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